TRAMP complex

The TRAMP complex (Trf4/Air2/Mtr4p Polyadenylation complex) is a multi-protein complex consisting of the RNA helicase Mtr4, a poly(A) polymerase (PAP) (either Trf4 or Trf5) and a zinc knuckle protein (either Air1 or Air2). The TRAMP complex interacts with the exosome complex in the nucleus of eukaryotic cells and is involved in the 3' end processing of ribosomal RNA and snoRNAs.^[1][2]

See also

• Ski complex

References

1. ^ LaCava et al.; Houseley, J; Saveanu, C; Petfalski, E; Thompson, E; Jacquier, A; Tollervey, D (2005). "RNA degradation by the exosome is promoted by a nuclear polyadenylation complex". Cell 121 (5): 713–24. doi:10.1016/j.cell.2005.04.029. PMID 15935758. 
2. ^ Vaňáčová et al.; Wolf, J; Martin, G; Blank, D; Dettwiler, S; Friedlein, A; Langen, H; Keith, G et al. (2005). "A New Yeast Poly(A) Polymerase Complex Involved in RNA Quality Control". PLoS Biology 3 (6): e189. doi:10.1371/journal.pbio.0030189. PMC 1079787. PMID 15828860. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1079787.